Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model.

Jiwon OhYeon Sung SonWan Hee KimOh-Kyeong KwonByung Jae Kang

Published in: Journal of orthopaedic surgery and research (2021)

Genetically modifying PDGF and HO-1 in MSCs is an effective strategy for treating OA, suggesting that PDGF-MSCs can be novel therapeutic agents for improving OA symptoms.

Keyphrases

mesenchymal stem cells
growth factor
knee osteoarthritis
umbilical cord
smooth muscle
vascular smooth muscle cells
bone marrow
cell therapy
rheumatoid arthritis
sleep quality
pi k akt
cell proliferation