Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.

Man LiuJingying ZhouXiaoyu LiuYu FengWeiqin YangFeng WuOtto Ka-Wing CheungHanyong SunXuezhen ZengWenshu TangMyth T S MokJohn WongPhilip Chun YeungPaul Bo San LaiZhiwei ChenHongchuan JinJie ChenStephen Lam ChanAnthony W H ChanKa Fai ToJoseph J Y SungMin-Hu Chen Alfred Sze-Lok Cheng

Published in: Gut (2019)

Our results signify how non-tumour-intrinsic properties in the desmoplastic microenvironment can be exploited to reinstate immunosurveillance, providing readily translatable combination strategies to empower HCC immunotherapy.

Keyphrases

stem cells
dendritic cells
transcription factor
cancer therapy
endothelial cells
binding protein
drug delivery