Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Menstrual Cycle Abnormalities, Hormonal Profile, and IGF-1 System in Polycystic Ovary Syndrome Patients: A Randomized, Placebo-Controlled Clinical Trial.
Sally KadouraMarwan AlhalabiAbdul Hakim NattoufPublished in: Advances in pharmacological sciences (2019)
Calcium and vitamin D supplements can support metformin effect on regulation of menstrual cycle irregularity in vitamin D-deficient/insufficient PCOS patients, but this effect is not associated with any significant changes in gonadotropins or IGF-1 system. These results suggest a possible role of calcium and vitamin D supplements in managing PCOS. However, further studies are needed to identify the underlying mechanisms. The Clinical Trial Registration Number is NCT03792984.
Keyphrases
- polycystic ovary syndrome
- clinical trial
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- insulin resistance
- study protocol
- peritoneal dialysis
- type diabetes
- double blind
- squamous cell carcinoma
- adipose tissue
- metabolic syndrome
- open label
- patient reported outcomes
- cell proliferation
- signaling pathway
- patient reported
- case control
- locally advanced