Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients.
Ozge Kizilay ManciniMariana AcevedoNesrine FazezAlexanne CuillerierAna Fernandez RuizDavid N HuynhYan BurelleGerardo FerbeyreMurray BaronMarc J ServantPublished in: Rheumatology (Oxford, England) (2021)
Oxidative stress-induced cellular senescence in SSc fibroblasts underlies their pro-inflammatory and pro-fibrotic phenotypes. Targeting redox imbalance of SSc fibroblasts enhances their in vitro functions and could be of relevance for SSc therapy.
Keyphrases
- systemic sclerosis
- interstitial lung disease
- end stage renal disease
- extracellular matrix
- dna damage
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- oxidative stress
- idiopathic pulmonary fibrosis
- stress induced
- cancer therapy
- stem cells
- bone marrow
- anti inflammatory
- cell therapy
- chemotherapy induced