Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy.
Victor NgSonali SinhaArdijana NovajJennifer MaNiamh McDermottIsaac X PeiAna Leda F LonghiniHelen E GrimsleyRui GardnerEzra Y RosenSimon N PowellFresia ParejaDiana L MandelkerAtif J KhanJeremy S SettonAnne RoulstonStephen MorrisMaria KoehlerNancy Y LeeJorge Sergio Reis-FilhoNadeem RiazPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Genotype-directed radiosensitization with ATRi and RT can unleash significant therapeutic benefit and could represent a novel approach to develop more effective combinatorial synthetic cytotoxic RT-based treatments.