Mild Hypothermia via External Cooling Improves Lung Function and Alleviates Pulmonary Inflammatory Response and Damage in Two-Hit Rabbit Model of Acute Lung Injury.
Onat AkyolSerdar DemirganAslıhan ŞengelenHasan Cem GüneyliDuygu Sultan OranFunda YildirimDamla HaktanırMehmet Salih SevdiKerem ErkalpAyşin SelcanPublished in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2022)
Mild TH with external cooling reduced lung inflammation and damage, whereas it resulted in partial improvement in gas exchanges. Our findings highlight that body temperature control may be a potentially supportive therapeutic option for regulating cytokine production and respiratory parameters in ALI/ARDS.
Keyphrases
- lung function
- inflammatory response
- oxidative stress
- lipopolysaccharide induced
- lps induced
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- cardiac arrest
- pulmonary hypertension
- acute respiratory distress syndrome
- toll like receptor
- extracorporeal membrane oxygenation
- room temperature
- mouse model
- carbon dioxide
- immune response
- respiratory tract
- ionic liquid