miRNA-221-3p in Endothelial Progenitor Cell-Derived Exosomes Accelerates Skin Wound Healing in Diabetic Mice.

Juan XuSuwen BaiYadi CaoLei LiuYang FangJuan DuLi LuoMingwei ChenBing ShenQiu Zhang

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

We concluded that miRNA-221-3p is one of the high-expressed miRNAs in EPC-derived exosomes and promoted skin wound healing in diabetic mice. The finding uncovers the molecular mechanism of EPC-derived exosomes and provides a potential novel approach to the clinical treatment of diabetic skin wounds.

Keyphrases

wound healing
mesenchymal stem cells
stem cells
endothelial cells
bone marrow
combination therapy
human health