Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing".

Chen-Yu Wang John E Froberg Roy BlumYesu JeonJeannie T Lee

Published in: Science (New York, N.Y.) (2017)

Chen et al (Reports, 28 October 2016, p. 468) proposed that an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chromosome inactivation. We reanalyzed their data and found that reported genotypes of mutants are not supported by the sequencing data. These inconsistencies preclude assessment of the role of LBR in Xist spreading.

Keyphrases

copy number
electronic health record
big data
single cell
emergency department
adverse drug
gene expression
deep learning