Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes.

Corinne G JolivaltM R AghanooriM C Navarro-DiazM M HanG SanchezL GuernseyD QuachK JoheP FernyhoughNigel A Calcutt

Published in: Journal of diabetes research (2022)

Efficacy of NSI-189 against dysfunction of the CNS and PNS function in type 2 diabetic rats was accompanied by improvement of mitochondrial function. NSI-189 exhibited actions at different levels of mitochondrial regulation in central and peripheral tissues.

Keyphrases

diabetic rats
oxidative stress
spinal cord injury
gene expression
working memory
blood brain barrier