Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m.
N I GorshkovAlexander E MiroslavovI Е АlekseevА А LumpovА Y МurkoI I GavrilovaN N SaprykinaМ А BezrukovaА I KipperV D KrasikovD N SuglobovM Y TyupinaЕ F PanarinPublished in: Journal of labelled compounds & radiopharmaceuticals (2017)
The procedure of the directed synthesis of N-vinylpyrrolidone-N-vinylformamide (VP-VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium-113m were developed. The metal-copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high-performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium-113m were optimized. It was shown that the VP-VFA-IDA copolymer firmly binds indium-113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP-VFA-IDA-In conjugates were found to be unstable in histidine challenge reaction.