Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.

Andrea SantangeloMarco BortolatoLaura J MosherGiuseppe CrescimannoGiuseppe Di GiovanniEmanuele CassioliValdo RiccaMaurizio Casarrubea

Published in: CNS neuroscience & therapeutics (2018)

The results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS.

Keyphrases

mouse model
computed tomography
image quality
contrast enhanced
mental health
dual energy
magnetic resonance imaging
positron emission tomography
magnetic resonance
obsessive compulsive disorder
case report