Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.
Andrea SantangeloMarco BortolatoLaura J MosherGiuseppe CrescimannoGiuseppe Di GiovanniEmanuele CassioliValdo RiccaMaurizio CasarrubeaPublished in: CNS neuroscience & therapeutics (2018)
The results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS.