Atroposelective Kinetic Resolution of 8 H -Indeno[1,2- c ]thiophen-8-ols via Pd-Catalyzed C-C Bond Cleavage Reaction.

The present work demonstrates a palladium-catalyzed kinetic resolution/ring-opening reaction of 8 H -indeno[1,2- c ]thiophen-8-ols. The reaction proceeds in a highly regioselective manner, and both optically active thiophene-phenyl atropisomers and stereogenic 8 H -indeno[1,2- c ]thiophen-8-ols were obtained with high enantiomeric excesses. The synthetic applications of the obtained thiophenyl atropisomers were briefly investigated.