Evaluating anthracycline cardiotoxicity associated single nucleotide polymorphisms in a paediatric cohort with early onset cardiomyopathy.

Timothy N McOwanLauren A CraigAnne TripdayonisKathy KaravendzasMichael M CheungEnzo R PorrelloRachel ConyersDavid A Elliott

Published in: Cardio-oncology (London, England) (2020)

We conclude that previously identified missense SNPs are present within a paediatric cohort with early onset heart damage induced by anthracyclines. However, these SNPs require further replication cohorts and functional validation before being deployed to assess anthracycline cardiotoxicity risk in the clinic.

Keyphrases

early onset
late onset
intensive care unit
heart failure
genome wide
emergency department
primary care
oxidative stress
intellectual disability
genome wide association
gene expression