The high incidence of severe adverse events due to pyrazinamide in elderly patients with tuberculosis.

Byoung Soo KwonYoulim KimSang Hoon LeeSung Yoon LimYeon Joo LeeJong Sun ParkYoung-Jae ChoHo Il YoonChoon-Taek LeeJae Ho Lee

Published in: PloS one (2020)

PZA was the most common drug associated with SAEs among the first-line anti-TB drugs, and old age was an independent factor for SAE occurrence. This study suggests that the early recognition of whether the causative agent is PZA may improve effective treatment compliance, particularly in elderly patients.

Keyphrases

mycobacterium tuberculosis
drug induced
risk assessment
risk factors
pulmonary tuberculosis
middle aged
early onset
adverse drug
hiv aids
combination therapy
hiv infected
smoking cessation