Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver.

Marine AndresNathalie HennuyerKhamis ZibarMarie Bicharel-LeconteIsabelle DuplanEmmanuelle EnéeEmmanuelle VallezAdrien HerledanAnne LoyensBart StaelsBenoit DeprezPeter van EndertRebecca Deprez-PoulainSteve Lancel

Published in: British journal of pharmacology (2024)

These results unravel a novel role for IDE in the regulation of ER stress and development of hepatic steatosis. These findings pave the way to innovative strategies modulating IDE to treat metabolic diseases.

Keyphrases

type diabetes
signaling pathway
endoplasmic reticulum stress
amino acid
binding protein
endoplasmic reticulum
metabolic syndrome
adipose tissue