Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.
De Sadeleer LaurensJohn E McDonoughJonas Christian SchuppXiting YanArno VanstapelAnke Van HerckStephanie EveraertsVincent GeudensAnnelore SacreasTinne GoosCeline AelbrechtTim S NawrotDries S MartensDominique ScholsSandra ClaesJohny A VerschakelenErik K VerbekenMaximilian AckermannAnabelle DecottigniesManon MahieuTillie-Louise HackettJames C HoggBart M VanaudenaerdeStijn E VerledenNaftali KaminskiWim A WuytsPublished in: American journal of respiratory and critical care medicine (2021)
We identified six molecular traits which characterise the morphological progression of fHP and associate with in vivo clinical behaviour. Comparing IPF with fHP, the transcriptome landscape was determined considerably by local disease extent, rather than by diagnosis alone.