A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging.

Yaser Hadi GholamiHushan YuanMoses Q WilksRichard Maschmeyer Marc D Normandin Lee JosephsonGeorges El FakhriZdenka Kuncic

Published in: International journal of nanomedicine (2020)

Our results demonstrate FH is a highly suitable SPION-based platform for chelate-free labeling of PET tracers for hybrid PET-MR. The high RCY and RCP confirmed the robustness of the chelate-free HIR technique. An overall image quality gain was achieved compared to PET- or MR-alone imaging with a relatively low dosage of [89Zr]Zr-FH. Additionally, FH is suitable as a dual-mode T1/T2 MR image contrast agent.

Keyphrases

pet imaging
computed tomography
contrast enhanced
positron emission tomography
pet ct
image quality
magnetic resonance
magnetic resonance imaging
high throughput
high resolution
dual energy
deep learning