Fragmentation of a Monoclonal Antibody by Peroxotungstate.

Hasitha RathnayakaOlivier MozziconacciAlavattam SreedharaChristian Schöneich

Published in: Pharmaceutical research (2018)

Fragmentation of the mAb by peroxotungstate is proposed to occur through inter-chain disulfide bond oxidation to form thiosulfinate (CyS(═O)SCy) and thiosulfonate [CyS(═O)2SCy], followed by hydrolysis.

Keyphrases

monoclonal antibody
hydrogen peroxide
anaerobic digestion
electron transfer
transition metal