Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.

Hannah ClarkRaquel GranellJohn A CurtinDanielle BelgraveAngela SimpsonClare MurrayA John HendersonAdnan CustovicLavinia Paternoster

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)

We have shown complex, but distinct patterns of genetic associations with LCADs, suggesting that heterogeneous mechanisms underlie individual disease trajectories. Establishing the combination of allergic diseases with which each genetic variant is associated may inform therapeutic development and/or predictive modelling.

Keyphrases

genome wide
atopic dermatitis
copy number
depressive symptoms
allergic rhinitis
dna methylation