A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma.

Kevin M Magnaye Katherine A NaughtonJanel HuffmanD Kyle HogarthEdward T NaureckasSteven R WhiteCarole Ober

Published in: The European respiratory journal (2021)

Reduced A-to-I editing of position 5 of miR-200b-3p in lower airway cells from moderate-to-severe asthmatic subjects may lead to overexpression of SOCS1 and impaired cytokine signalling. We propose ADAR-mediated editing as an epigenetic mechanism contributing to features of moderate-to-severe asthma in adulthood.

Keyphrases

crispr cas
high intensity
induced apoptosis
dna methylation
cell proliferation
gene expression
cell cycle arrest
transcription factor
lung function
endoplasmic reticulum stress
early life
cystic fibrosis