Effect of albumin substitution on pharmacokinetics of piperacillin/tazobactam in patients with severe burn injury admitted to the ICU.

Beatrix WulkersdorferFelix BergmannLisa AmannAlexandra Fochtmann-FranaValentin Al JalaliElizaveta KurdinaEdith LacknerSebastian G WichaChristoph DornBruno SchäferGerald IhraThomas RathChristine RadtkeMarkus Zeitlinger

Published in: The Journal of antimicrobial chemotherapy (2023)

Albumin supplementation had little impact on the PK of piperacillin/tazobactam. After albumin supplementation, there was a numerical increase in mean AUC0-8 of total and unbound piperacillin/tazobactam, whereas similar Cmax values were observed. Future studies may investigate the effect of albumin supplementation on drugs with a higher plasma protein binding.

Keyphrases

gram negative
intensive care unit
binding protein
early onset
multidrug resistant
wound healing
case control
extracorporeal membrane oxygenation