A potential role of TLR2 in xenograft rejection of porcine iliac endothelial cells: An in vitro study.

Jicheng ChenHanchao GaoLinLin ChenXisheng WangZongpei SongDavid K C CooperZepeng QuZhiming CaiLisha Mou

Published in: Xenotransplantation (2019)

(i) TLR2 is significantly upregulated in PIECs by human serum, (ii) the elevated TLR2 participates in the chemotaxis of inflammatory cells through the secretion of chemokine CCL2 and CXCL8, and (iii) blockade of TLR2 would be beneficial for xenograft survival.

Keyphrases

toll like receptor
inflammatory response
immune response
endothelial cells
nuclear factor
induced apoptosis
oxidative stress
cell cycle arrest
cell proliferation
liver injury
vascular endothelial growth factor