Immune gene expression profiling reveals heterogeneity in luminal breast tumors.

Bin ZhuLap Ah TseDifei WangHela KokaTongwu ZhangMustapha AbubakarPriscilla LeeFeng WangCherry WuKoon Ho TsangWing-Cheong ChanSze Hong LawMengjie LiWentao LiSuyang WuZhiguang LiuBixia HuangHan ZhangEric TangZhengyan KanSoohyeon LeeYeon Hee ParkSeok Jin NamMingyi WangXuezheng SunKristine JonesBin ZhuAmy HutchinsonBelynda HicksLudmila Prokunina-OlssonJianxin ShiMontserrat Garcia-ClosasStephen ChanockXiaohong R Yang

Published in: Breast cancer research : BCR (2019)

Our findings suggest that immune gene expression and associated genomic features could be useful to further stratify luminal BC beyond the current luminal A/B classification and a subset of luminal BC patients may benefit from checkpoint immunotherapy, at least in Asian populations.

Keyphrases

gene expression
end stage renal disease
dna methylation
ejection fraction
newly diagnosed
single cell
chronic kidney disease
machine learning
dna damage
prognostic factors
deep learning
cell cycle
copy number
genome wide
patient reported