Metabolic consequences for mice lacking Endosialin: LC-MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock-out mice.

Emily G ArmitageAlan BarnesKieran PatrickJanak BecharMatthew J HarrisonGareth G LaveryG Ed RaingerChristopher D BuckleyNeil J LoftusIan D WilsonAmy J Naylor

Published in: Metabolomics : Official journal of the Metabolomic Society (2021)

Overall these results show a clear and protective metabolic consequence of CD248 deletion in mice, implicating CD248 in lipid metabolism or trafficking and opening new avenues for further investigation using anti-CD248 targeting agents.

Keyphrases

high fat diet induced
nk cells
adipose tissue
wild type
insulin resistance
cancer therapy