Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

D J PolleyK MiharaR RamachandranH VliagoftisB RenauxM SaifeddineM O DainesS BoitanoMorley D Hollenberg

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)

We have identified three different serine proteinases from the German cockroach that may, via PAR2 activation, play different roles for allergen sensitization in vivo and may represent attractive therapeutic targets for asthma.

Keyphrases

allergic rhinitis
protein kinase
chronic obstructive pulmonary disease
single cell
lung function
binding protein
air pollution