Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models.
Outi KeinänenKimberly FungJacob PouratVilma JallinojaDelphine VivierNagaVara Kishore PillarsettyAnu J AiraksinenJason S LewisBrian M ZeglisMirkka P SarparantaPublished in: EJNMMI research (2017)
We could successfully visualize the tumours by using cetuximab and trastuzumab in pretargeted PET imaging despite the challenging circumstances where the antibody is internalized and there is still some unbound antibody circulating in the blood flow. This clearly demonstrates the potential of a pretargeted approach for targeting internalizing antigens and warrants development of pharmacokinetic optimization of the biorthogonal reactants to this end.
Keyphrases
- pet imaging
- blood flow
- epidermal growth factor receptor
- metastatic colorectal cancer
- positron emission tomography
- metastatic breast cancer
- locally advanced
- wild type
- dendritic cells
- cancer therapy
- computed tomography
- tyrosine kinase
- radiation therapy
- human health
- drug delivery
- risk assessment
- rectal cancer
- climate change