Simultaneous attenuation of hyperglycemic memory-induced retinal, pulmonary, and glomerular dysfunctions by proinsulin C-peptide in diabetes.
Hye-Yoon JeonChan-Hee MoonEun-Bin KimNilofar Danishmalik SayyedAh-Jun LeeKwon-Soo HaPublished in: BMC medicine (2023)
Overall, our findings demonstrate that C-peptide supplementation simultaneously attenuates vascular and neuronal dysfunctions in the retina, lung, and glomerulus of insulin-supplemented diabetic mice.
Keyphrases
- type diabetes
- high glucose
- diabetic retinopathy
- glycemic control
- optic nerve
- pulmonary hypertension
- cardiovascular disease
- optical coherence tomography
- endothelial cells
- diabetic rats
- working memory
- drug induced
- oxidative stress
- diabetic nephropathy
- adipose tissue
- skeletal muscle
- cerebral ischemia
- blood brain barrier