Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model.
Aurora BarberáImma RaurellTeresa García-LezanaManuel Torres-ArauzMiren BravoDiana HideMar GilMaría Teresa SalcedoJoan GenescàMaría MartellSalvador AugustinPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Liver steatosis per se (in absence of fibrosis) can induce PH through a decrease in the sinusoidal area secondary to the increase in hepatocyte area in a long-term diet-induced rat model of NASH. Image analysis of the sinusoidal area might predict the presence of PH.