Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes.
Gareth S D PurvisFausto ChiazzaJianmin ChenRodrigo Azevedo-LoiolaLukas MartinDennis H M KustersChris ReutelingspergerNikolaos FountoulakisLuigi GnudiMuhammed M YaqoobMassimo CollinoChristoph ThiemermannEgle SolitoPublished in: Diabetologia (2017)
Overall, these results demonstrate that ANXA1 plasma levels are elevated in individuals with type 1 diabetes independent of a significant impairment in renal function. Furthermore, in mouse models with STZ-induced type 1 diabetes, ANXA1 protects against cardiac and renal dysfunction by returning MAPK signalling to baseline and activating pro-survival pathways (Akt). We propose ANXA1 to be a potential therapeutic option for the control of comorbidities in type 1 diabetes.