A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

Blandine RammaertPierre-Yves BochudAnne-Sophie BrunelAgnieszka WojtowiczSophie CandonMaria Pilar Gallego HernanzOlivier Lortholary

Published in: Open forum infectious diseases (2023)

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

Keyphrases

genome wide
candida albicans
oxidative stress
cell cycle
case report
dna methylation
gene expression
transcription factor
mass spectrometry
high density
genome wide analysis
high speed