Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression.

Anastasiya KazachenkaGeorge R YoungJan AttigChrysoula KordellaEleftheria LamprianidouEmmanuela ZouliaGeorge VrachioliasMenelaos PapoutselisElsa BernardElli PapaemmanuilIoannis KotsianidisGeorge Kassiotis

Published in: Genome medicine (2019)

Our study identifies the developmentally regulated transcriptional signatures of protein-coding and non-coding genes, rather than EREs, as correlates of a favourable response of MDS and CMML patients to 5-AZA treatment and offers novel candidates for further evaluation.

Keyphrases

genome wide
end stage renal disease
gene expression
dna methylation
ejection fraction
newly diagnosed
transcription factor
chronic kidney disease
peritoneal dialysis
oxidative stress
amino acid
mesenchymal stem cells
replacement therapy
patient reported
genome wide analysis
heat shock protein