Ticagrelor inverse agonist activity at the P2Y 12 receptor is non-reversible versus its endogenous agonist ADP.
Jawad KhalilTudor DimofteTimothy RobertsMichael KeithKumuthu AmaradasaMatthew S HindleSukhinder BancroftJames L HutchinsonKhalid NaseemThomas JohnsonStuart J MundellPublished in: British journal of pharmacology (2023)
R agonist ADP. This study highlights the potential clinical need for novel ticagrelor reversal strategies in patients with spontaneous major bleeding and bleeding associated with urgent invasive procedures.