RBP4 promotes denervation-induced muscle atrophy through STRA6-dependent pathway.

Kang-Zhen ZhangJia-Wen LiJin-Shui XuZheng-Kai ShenYu-Shuang LinCan ZhaoXiang LuYun-Feng RuiWei Gao

Published in: Journal of cachexia, sarcopenia and muscle (2024)

In conclusion, our data reveal that RBP4 promotes fat infiltration and muscle atrophy through a STRA6-dependent and JAK2/STAT3 pathway-mediated mechanism in denervated skeletal muscle. Our results suggest that lowering RBP4 levels might serve as a promising therapeutic approach for prevention and treatment of muscle atrophy.

Keyphrases

skeletal muscle
insulin resistance
adipose tissue
electronic health record
high glucose
oxidative stress
metabolic syndrome
combination therapy