Mitochondria-Targeting Plasmonic Spiky Nanorods Increase the Elimination of Aging Cells in Vivo.
Meiru LuAihua QuSi LiMaozhong SunLiguang XuHua KuangChuanlai XuPublished in: Angewandte Chemie (International ed. in English) (2020)
Cellular senescence is stress-induced, irreversible growth arrest, and is thought to impair tissue function. The clearance of senescent cells can delay the features of senescence. Herein, we report the development of plasmonic core-shell spiky nanorods (CSNRs) surface-modified with an anti-beta-2-microglobulin (aB2MG) antibody and triphenylphosphonium (TPP), to target the mitochondria in senescent cells. aB2MG-TPP@CSNRs irradiated with near-infrared (NIR) light selectively caused mitochondrial damage and apoptosis of senescent cells with relatively low NIR light power, and the ability of CSNRs to activate and amplify the immune response in vitro and in vivo was discovered. The photo-induced generation of reactive oxygen species (ROS) resulted in senescent-cell apoptosis and immune adjuvant effect by CSNRs accelerated the clearance of senescent cells in mice. This study opens the way for the use of precisely regulated plasmonic nanostructures for immune adjuvant and photo-induced apoptosis for age-related senescence.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest
- oxidative stress
- signaling pathway
- stress induced
- cell death
- reactive oxygen species
- dna damage
- early stage
- pi k akt
- type diabetes
- cell proliferation
- gold nanoparticles
- single molecule
- drug delivery
- transcription factor
- insulin resistance
- high glucose
- quantum dots
- visible light