Design of new glycosyl-O-fipronil conjugates with improved hydrolysis efficiency assisted by molecular simulations.

A strategy for the development of new phloem-mobile pesticides was proposed: linking a glycosyl group to the existing pesticide structure with a linear alkyl connection approximately four carbons in length. The resultant conjugates feature not only good phloem mobility, but also potential high bioactivity due to the efficient release of active pesticide components under the action of glucosidase. © 2022 Society of Chemical Industry.