A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity.

Michelle Sadeh Helen Toledano Ian Joseph Cohen

Published in: Journal of pediatric hematology/oncology (2022)

Neuropsychological evaluation supported inadequate FA being the cause of neurocognitive damage after high-dose methotrexate and that adequate FA rescue prevents this complication.

Keyphrases

high dose
stem cell transplantation
low dose
mouse model
oxidative stress
mild cognitive impairment
case control