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A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.

Michael T BromanRangarajan D NadadurCarlos Perez-CervantesOzanna Burnicka-TurekSonja LazarevicAnna GamsBrigitte LaforestJeffrey D SteimleSabrina IddirZhezhen WangLinsin SmithStefan R MazurekHarold E OliveyPingzhu ZhouMargaret GadekKaitlyn M ShenZoheb KhanJoshua W M TheisenXinan Holly YangKohta IkegamiIgor R EfimovWilliam T PuChristopher R WeberElizabeth M McNallyEric C SvenssonIvan P Moskowitz
Published in: Circulation (2024)
Transcriptional changes in the atria observed in human HF directly antagonize the atrial rhythm gene regulatory network, providing a genomic link between HF and AF risk independent of atrial remodeling.
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