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CGINet: graph convolutional network-based model for identifying chemical-gene interaction in an integrated multi-relational graph.

Wei WangXi YangChengkun WuCanqun Yang
Published in: BMC bioinformatics (2020)
We study three model implementations CGINet-1/2/3 with various components and compare them with baseline approaches. As the experimental results suggest, our models exhibit competitive performances on identifying chemical-gene interactions. Besides, the subgraph perspective and the latent link both play positive roles in learning much more informative node embeddings and can lead to improved prediction.
Keyphrases
  • copy number
  • neural network
  • genome wide
  • convolutional neural network
  • genome wide identification
  • dna methylation
  • deep learning
  • genome wide analysis
  • network analysis