Boosting phagocytosis and anti-inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease models.

Daniela LeccaElzbieta JandaGiovanna MulasAndrea DianaConcetta MartinoFabrizio AngiusStefano SpolituMaria Antonietta CasuGabriella SimbulaLaura BoiBarbara BatettaSaturnino SpigaAnna R Carta

Published in: British journal of pharmacology (2018)

This study adds a novel mechanism for PPARγ-mediated neuroprotection in PD and suggests that increasing phagocytic activity and anti-inflammatory markers may represent an effective disease-modifying approach.

Keyphrases

anti inflammatory
brain injury
insulin resistance
cerebral ischemia
inflammatory response
neuropathic pain
type diabetes
adipose tissue
spinal cord
spinal cord injury
blood brain barrier