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Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Anna D KosinskaAbdul MoeedNina KallinJulia FestagJinpeng SuKatja SteigerMarie-Louise MichelUlrike ProtzerPercy A Knolle
Published in: Scientific reports (2019)
Therapeutic vaccination against chronic hepatitis B must overcome high viral antigen load and local regulatory mechanisms that promote immune-tolerance in the liver and curtail hepatitis B virus (HBV)-specific CD8 T cell immunity. Here, we report that therapeutic heterologous HBcore-protein-prime/Modified-Vaccinia-Virus-Ankara (MVA-HBcore) boost vaccination followed by CpG-application augmented vaccine-induced HBcAg-specific CD8 T cell-function in the liver. In HBV-transgenic as well as AAV-HBV-transduced mice with persistent high-level HBV-replication, the combination of therapeutic vaccination with subsequent CpG-application was synergistic to generate more potent HBV-specific CD8 T cell immunity that improved control of hepatocytes replicating HBV.
Keyphrases
  • hepatitis b virus
  • liver failure
  • dna methylation
  • transcription factor
  • sars cov
  • gene expression
  • drug delivery
  • metabolic syndrome
  • skeletal muscle
  • drug induced
  • high fat diet induced
  • endothelial cells
  • stress induced