Ketamine induces rapid antidepressant effects via the autophagy-NLRP3 inflammasome pathway.

Dongbin LyuFan WangMengke ZhangWeichieh YangHaijing HuangQinte HuangChenglin WuNuoshi QianMeiti WangHuanfei ZhangSichai ZhengJing ChenYingmei FuChen ZhangZezhi LiWu Hong

Published in: Psychopharmacology (2022)

Our findings demonstrate that sub-anesthetic doses of ketamine exert their antidepressant-like effects by inhibiting inflammation and initiating neuroprotection via autophagy activation. These data might help expand future investigations on the antidepressant properties of ketamine.

Keyphrases

nlrp inflammasome
major depressive disorder
oxidative stress
signaling pathway
pain management
cell death
endoplasmic reticulum stress
electronic health record
chronic pain
cerebral ischemia