Rechallenge With High-Dose Methotrexate After Treatment With Glucarpidase in Adult Patients With Lymphoma.

Huong L Truong Jason N Barreto Kristin C Cole Paul Joseph Hampel Ivana N Micallef Grzegorz S Nowakowski Gita Thanarajasingam Carrie A Thompson Yucai Wang Thomas E Witzig Sandra M Herrmann Nelson R Leung

Published in: JCO oncology practice (2024)

In selected adults with lymphoma who required glucarpidase for toxic MTX levels after administration of high-dose MTX, resumption of MTX therapy at lower doses is safe. Patients selected for MTX resumption had experienced less severe AKI during the previous cycle compared with those not selected for MTX resumption.

Keyphrases

high dose
low dose
stem cell transplantation
end stage renal disease
diffuse large b cell lymphoma
ejection fraction
newly diagnosed
acute kidney injury
prognostic factors
peritoneal dialysis
patient reported outcomes
bone marrow
drug induced