Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis.

Sedighegh MadaniMahdiyeh AmanzadiHamid Reza AghayanAria SetudehNegar RezaeiMahtab RouhifardBagher Larijani

Published in: Systematic reviews (2022)

Based on the results of this meta-analysis, the MSC and its combination with HSC could be considered as "Safe Cell" for SCT in T1DM. Furthermore, to evaluate the SCT efficacy, calculation of insulin TDD (U/kg/day), AUC of c-peptide, and adjusted HbA1c are highly recommended.

Keyphrases

systematic review
cell therapy
bone marrow
mesenchymal stem cells
glycemic control
type diabetes
meta analyses
umbilical cord
combination therapy
case control
weight loss