Acotiamide attenuates central urocortin 2-induced intestinal inflammatory responses, and urocortin 2 treatment reduces TNF-α productions in LPS-stimulated macrophage cell lines.
Hiroshi YamawakiSeiji FutagamiNoriko SakasegawaMakoto MurakamiShuhei AgawaGo IkedaHiroto NodaKumiko KiritaKatya GudisKazutoshi HiguchiYasuhiro KodakaNobue UekiKatsuhiko IwakiriPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
Central and in vitro treatments of Ucn 2 affected intestinal inflammatory responses, respectively, and acotiamide improved them.