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Bicarbonate-binding catalysis for the enantioselective desymmetrization of keto sulfonium salts.

José AlemánJorge Humbrías-MartínRoberto Del Río-RodríguezFernando Aguilar-GalindoSergio Diaz-TenderoJosé A Fernández-Salas
Published in: Nature communications (2024)
Herein, an enantioselective desymmetrization of cyclic keto sulfonium salts through enantioselective deprotonation/ring opening process by anion-binding catalysis is presented. We report a squaramide/HCO 3 - complex as catalytic active species which is able to stereo-differentiate two enantiomeric protons, triggering the ring opening event taking advantage of the great tendency of sulfonium salts to act as leaving groups. Thus, this desymmetrization methodology give rise to β-methylsulfenylated sulfa-Michael addition type products with excellent yields and very good enantioselectivities. The bifunctional organocatalyst has been demonstrated to be capable of activating simultaneously the base and the keto sulfonium salt by DFT calculations and experimental proofs.
Keyphrases
  • ionic liquid
  • density functional theory
  • dna binding
  • signaling pathway
  • molecular dynamics
  • molecular dynamics simulations
  • binding protein
  • crystal structure
  • visible light
  • mass spectrometry
  • capillary electrophoresis