FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension.

Alice BourgeoisCaroline LambertKarima HabboutBenoit RanchouxStéphanie Paquet-MarceauIsabelle TrinhSandra Breuils-BonnetRenée ParadisValérie NadeauRoxane PaulinSteeve ProvencherSébastien BonnetOlivier Boucherat

Published in: Journal of molecular medicine (Berlin, Germany) (2017)

FOXM1 is overexpressed in human PAH-PASMCs and PAH animal models. FOXM1 promotes PAH-PASMC proliferation and resistance to apoptosis. Pharmacological inhibition of FOXM1 improves established PAH in the MCT and Su/Hx rat models. FOXM1 may be a novel therapeutic target in PAH.

Keyphrases

pulmonary arterial hypertension
pulmonary artery
pulmonary hypertension
polycyclic aromatic hydrocarbons
smooth muscle
coronary artery
oxidative stress
endothelial cells
cell death
endoplasmic reticulum stress
single cell
cell therapy
bone marrow
mesenchymal stem cells