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Small Non-Coding RNAs in Human Cancer.

Qunli XiongYaguang ZhangJunjun LiQing Zhu
Published in: Genes (2022)
Small non-coding RNAs are widespread in the biological world and have been extensively explored over the past decades. Their fundamental roles in human health and disease are increasingly appreciated. Furthermore, a growing number of studies have investigated the functions of small non-coding RNAs in cancer initiation and progression. In this review, we provide an overview of the biogenesis of small non-coding RNAs with a focus on microRNAs, PIWI-interacting RNAs, and a new class of tRNA-derived small RNAs. We discuss their biological functions in human cancer and highlight their clinical application as molecular biomarkers or therapeutic targets.
Keyphrases
  • papillary thyroid
  • human health
  • endothelial cells
  • squamous cell
  • risk assessment
  • induced pluripotent stem cells
  • squamous cell carcinoma
  • multidrug resistant
  • young adults
  • childhood cancer