Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models.
Rahul MittalGrant KeithMitchel LaceyJoana R N LemosJeenu MittalAmro AssayedKhemraj HiraniPublished in: PloS one (2024)
Our systematic review delves into the intricate relationship between DM and hearing impairment in animal models. Future research should focus on targeted therapies to enhance cochlear mitochondrial function, alleviate oxidative stress, and regulate apoptosis. The association between SNHL and social isolation as well as cognitive decline underscores the necessity for innovative therapeutic modalities addressing yet undiscovered mechanisms. Translating findings from animal models to human studies will validate these findings, offering a synergistic approach to effectively manage DM-associated co-morbidities such as hearing impairment.
Keyphrases
- hearing loss
- cognitive decline
- oxidative stress
- systematic review
- mild cognitive impairment
- endothelial cells
- glycemic control
- meta analyses
- mental health
- healthcare
- physical activity
- dna damage
- cell death
- cell cycle arrest
- current status
- type diabetes
- induced pluripotent stem cells
- ischemia reperfusion injury
- diabetic rats
- stem cells
- induced apoptosis
- adipose tissue
- metabolic syndrome
- cancer therapy
- weight loss
- signaling pathway
- heat stress
- pi k akt