Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.
Joseph S ReddyLaura HeathAbby Vander LindenMariet AllenKatia de Paiva LopesFatemeh SeifarErming WangYiyi MaWilliam L PoehlmanZachary S QuicksallAlexi RunnelsYanling WangDuc M DuongLuming YinKaiming XuErica S ModesteAnantharaman ShantaramanEric B DammerLingyan PingStephanie R OatmanJo ScanlanCharlotte HoMinerva M CarrasquilloMerve AtikGeovanna YepezAdriana O MitchellThuy T NguyenXianfeng ChenDavid X MarquezHasini ReddyHarrison XiaoSudha SeshadriRichard MayeuxStefan ProkopEdward B LeeGeidy E SerranoThomas G BeachAndrew F TeichVarham HaroutunianEdward J FoxMarla GearingAliza WingoThomas WingoJames J LahAllan I LeveyDennis W DicksonLisa L BarnesPhilip De JagerBin ZhangDavid BennettNicholas T SeyfriedAnna K GreenwoodNilüfer Ertekin-TanerPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.