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BDNF rs6265 polymorphism methylation in Multiple Sclerosis: A possible marker of disease progression.

Viviana NocitiMassimo SantoroDavide QuarantaFrancesco Antonio LosavioChiara De FinoRocco GiordanoNicole Piera PalombaPaolo Maria RossiniFranca Rosa GueriniMario ClericiDomenico CaputoMassimiliano Mirabella
Published in: PloS one (2018)
In patients with a high disease progression the hypomethylation of the BDNF gene could increase the secretion of the protective neurotrophin, so epigenetic modifications could be the organism response to limit a brain functional reserve loss. Our study suggests that the percentage of methylation of the BDNF gene could be used as a prognostic factor for disease progression toward a high disability in MS patient.
Keyphrases
  • multiple sclerosis
  • genome wide
  • prognostic factors
  • dna methylation
  • white matter
  • stress induced
  • copy number
  • gene expression
  • genome wide identification
  • case report
  • mass spectrometry
  • ms ms
  • genome wide analysis